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给5种哺乳动物iv双吡啶单肟HI—6 20mg/kg,其药物代谢动力学均呈二室开放模型,部分药动学参数可表示为体重的指数函数。将5种动物的采血时间转换为生理等价时间,建立了预测人血浆中HI—6浓度的经验函数式。经人体资料验证,预测值与实测值基本一致。
To 5 kinds of mammal iv dipyridamole mono-oxime HI-6 20mg / kg, its pharmacokinetics showed a two-compartment open model, part of the pharmacokinetic parameters can be expressed as an exponential function of body weight. The time of collecting blood from five kinds of animals was converted into physiologically equivalent time, and an empirical function to predict the concentration of HI-6 in human plasma was established. The body data validation, the predicted value and the measured value is basically the same.