用体外细胞培养和实验动物感染模型观察了石榴皮抗Ⅱ型生殖器疱疹病毒（ＨＳＶ－２）作用。体外石榴皮提取液具有多环节的抗ＨＳＶ－２活性，尤以直接灭活和阻碍ＨＳＶ－２吸附效果明显。石榴皮栓剂经阴道内预防性用药，能防止ＨＳＶ－２感染的发生，小剂量石榴皮栓剂（５０ｍｇ）可减轻临床损害，阴道内病毒分泌减少，血清抗体滴度降低。大剂量石榴皮栓剂（１００ｍｇ）则能完全抑制ＨＳＶ－２感染，且ＰＣＲ检测未发现潜伏ＨＳＶ－２ＤＮＡ存在。 The effect of pomegranate peel against type II genital herpes virus (HSV-2) was observed using in vitro cell culture and experimental animal infection models. Pomegranate peel extract in vitro has multiple aspects of anti-HSV-2 activity, especially in direct inactivation and hinder the adsorption of HSV-2. Intravaginal prophylactic administration of pomegranate suppositories can prevent the occurrence of HSV-2 infection. Small doses of pomegranate suppository (50 mg) can reduce clinical damage, reduce viral secretion in the vagina, and reduce serum antibody titer. Large doses of pomegranate septic suppositories (100 mg) completely inhibited HSV-2 infection, and no latent HSV-2 DNA was detected by PCR.