【摘 要】
：
目的:探讨乳腺癌病人肠道菌群物种多样性、丰度等方面差的异性,分析乳腺癌病人肠道菌群与焦虑抑郁情绪的相关性.方法:选择2019年10月至2020年10月安徽省蚌埠医学院第一附属医院肿瘤外科收治的乳腺癌病人30例,同期选取本院健康体检中心体检人员15例,依据焦虑自评量表、抑郁自评量表评分将研究对象分为乳腺癌有焦虑抑郁情绪组(BCAD组)、乳腺癌无焦虑抑郁情绪组(BCWAD组),非乳腺癌无焦虑抑郁情绪组(HWAD组),每组各15人.收集三组人群粪便标本进行测序,并进行肠道菌群和焦虑抑郁情绪相关性分析.结果:BC
【机 构】
：
蚌埠医学院第一附属医院护理部,安徽蚌埠233003;蚌埠医学院第一附属医院肿瘤外科,安徽蚌埠233003;蚌埠医学院护理学院,安徽蚌埠233004;蚌埠医学院外文教研室,安徽蚌埠233004
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目的:探讨乳腺癌病人肠道菌群物种多样性、丰度等方面差的异性,分析乳腺癌病人肠道菌群与焦虑抑郁情绪的相关性.方法:选择2019年10月至2020年10月安徽省蚌埠医学院第一附属医院肿瘤外科收治的乳腺癌病人30例,同期选取本院健康体检中心体检人员15例,依据焦虑自评量表、抑郁自评量表评分将研究对象分为乳腺癌有焦虑抑郁情绪组(BCAD组)、乳腺癌无焦虑抑郁情绪组(BCWAD组),非乳腺癌无焦虑抑郁情绪组(HWAD组),每组各15人.收集三组人群粪便标本进行测序,并进行肠道菌群和焦虑抑郁情绪相关性分析.结果:BCAD组焦虑得分(58.80±5.27)分、抑郁得分(59.60±4.94)分,BCWAD组焦虑得分(36.53±4.52)分、抑郁得分(38.20±3.78)分,HWAD组焦虑得分(35.13±5.28)分、抑郁得分(32.33±4.37)分,差异有统计学意义(P＜0.05);高通量测序并生物信息学分析,三组的Shannon指数、Chao指数、Ace指数、Shannoneven指数和Coverage指数有统计学意义(P＜0.05),Simpson指数无统计学意义(P＞0.05);群落差异分析三组肠道菌群在门属水平有不同细菌存在差异(P＜0.05).BCAD组肠道主要作用菌群为unclassified-Lachnospiracea、Sutterellaceae、Desulfovibrionales、Escherichia-Shigella,BCWAD组肠道主要作用菌群为Lactobacillus、Flavonifractor菌属.Pearson分析显示Campylobacterales、Helicobacteraceae、Anaerolineaceae等抑郁评分呈显著正相关,与焦虑评分不相关性(P＞0.05).结论:乳腺癌有焦虑抑郁情绪病人肠道菌群多样性及丰度降低,在门属水平上有一定差异,主要作用菌群为unclassified-Lachnospiracea、Campylobacterales、Helicobacteraceae,提示菌群结构的差异可能在乳腺癌焦虑抑郁情绪发生中起一定作用.
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