背景:将补肾方药分别制成“外贴剂”和“口服剂”,根据“体表穴位-经络-内脏-靶器官”相关,分别用外贴穴位和口服两种不同的给药途径治疗骨质疏松,按照中医传统理论推测均会归入肾经”而发挥调节作“用,但实际上是否会有“靶向给药”的特异性?检测“下丘脑-垂体-靶腺”系统的激素,进一步分析肾、骨、子宫、甲状腺、睾丸等靶器官的雌激素受体和雄激素受体,观察归经与受体的相关性。“”设计:以骨质疏松大鼠为研究对象的完全随机设计,补肾方药不同给药途径对照实验研究。目的:探讨补肾方药对实验性骨质疏松垂体-甲状腺轴的影响。单位:河北医科大学中医学院。材料:实验于2000-01/2004-12在河北医科大学中西医结合基础实验室完成。选择3月龄健康SD雌性大鼠60只,体重(300±20)g。实验动物由河北省实验动物中心提供。大鼠在实验室常规喂养1周后,随机分成6组:正常对照组(10只);病理模型组(10只);补肾方药总成分按0.8g/100g体质量灌喂组10只;穴位贴剂外贴膀胱经穴位组10()(只);穴位贴剂外贴肾经穴位组(10只);穴位贴剂外贴非经非穴位组(10只)。方法:采用注射地塞米松建立骨质疏松模型,用抗骨松穴位贴剂(antagonismosteoporosisacupointpaste,AOAP)外贴穴位、非经非穴位、并与口服补肾方药比较治疗骨质疏松(OP),以 BACKGROUND: Kidney-building prescriptions are made into “external patch” and “oral” respectively, and are treated with external acupoints and oral two different routes of administration according to the “acupuncture points on body surface-meridians-viscera-target organs”. The quality is loose, according to traditional Chinese medicine theory, it is presumed that they will all be assigned to the kidney canal and play a regulatory role, but in fact whether there will be specificity of “targeted administration” to detect the hypothalamus-pituitary-target gland system. Hormones, further analysis of the estrogen receptor and androgen receptors in the target organs such as kidney, bone, uterus, thyroid, testis, etc., observed the correlation with the receptors. “”Design: completely randomized design of osteoporosis rats as the subject of study, a controlled experimental study of different routes of administration of kidney-tonifying herbs. Objective: To explore the effect of prescription for tonifying kidney on experimental pituitary-thyroid axis of osteoporosis. Unit: School of Traditional Chinese Medicine, Hebei Medical University. MATERIALS: The experiment was performed at the Basic Laboratory of Integrated Chinese and Western Medicine, Hebei Medical University from January 2000 to December 2004. 60 healthy SD female rats aged 3 months were selected and weighed (300±20) g. Laboratory animals were provided by Hebei Experimental Animal Center. Rats were routinely fed in the laboratory for 1 week and randomly divided into 6 groups: normal control group (10 rats); pathological model group (10 rats); kidney-invigorating herbs total composition: 0.8 g/100 g body weight; 10 groups; The patch was pasted on the acupoint group 10 () (only); the acupoint patch was applied on the kidney acupoint group (ten); the acupoint patch was applied on the non-acupoint group (ten). METHODS: Osteoporosis model was established by injection of dexamethasone. Osteoporosis (OP) was treated by anti-angiosomposite acupoint paste (AOAP) external acupoints, non-acupoint non-acupoints, and oral kidney-purification formulas.