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目的:探讨半量促性腺激素释放激素拮抗剂(GnRHA)方案对体外授精-胚胎移植(IVF-ET)超促排卵的临床结局。方法:回顾性分析272例行IVF-ET治疗的患者,半量GnRHA方案组(A组)共136个周期和GnRH激动剂(GnRHa)长方案组(B组)136个周期。比较2种控制性超促排卵(COH)方案的临床结局。结果:A组的Gn使用剂量、使用天数、获卵数、胚胎种植率和多胎率均小于B组(P<0.05),而受精率、卵裂率、优质胚胎形成率及临床妊娠率组间无统计学差异(P>0.05)。结论:对正常卵巢储备的患者COH后行IVF-ET结局而言,半量GnRHA方案可以取得与标准GnRHa长方案一样的效果,并可减少Gn的使用天数及剂量,减轻患者的负担。
Objective: To investigate the clinical effect of GnRHA regimen on IVF-ET hyperstimulation. Methods: A total of 136 cycles of 272 cycles of GnRH regimen (group A) and 136 cycles of GnRHa regimen (group B) were retrospectively analyzed in 272 patients undergoing IVF-ET. The clinical outcomes of two controlled ovarian hyperstimulation (COH) regimens were compared. Results: The dose of Gn, the number of days of use, the number of oocytes retrieved, the rate of embryo implantation and the rate of multiple births in group A were all less than those in group B (P <0.05), while the rates of fertilization, cleavage, quality embryo formation and clinical pregnancy rate No statistical difference (P> 0.05). CONCLUSION: The half-dose GnRHA regimen can achieve the same effect as the standard GnRHa regimen in patients with normal ovarian reserve after IVF-ET in COH and can reduce the number of days and dosage of Gn and reduce the burden on patients.