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用24小时pH动态监测分别观察西沙必利(普瑞博思)和雷尼替丁治疗21例反流性食管病的抗反流效果,观察两种药物对胃内pH的影响与抗胃食管反流(GER)作用的相关性。结果表明,西沙必利组和雷尼替丁组治疗后食管酸反流指数均较服药前下降,两组间下降指数比较无显著性差异(P>0.05)。西沙必利组对胃内pH无影响,雷尼替丁组可降低胃内pH<1、pH<2和pH<3的总时间(％),平均pH和中位pH升高,两组比较差异显著(P<0.01)。西沙必利组和雷尼替丁组服药后对胃内pH的影响与食管酸反流指数变化无相关性(r=-0.436和-0.341,均P>0.05)。研究表明,西沙必利与雷尼替丁均具有确实的抗GER作用,疗效可比但作用机理不同,临床应合理选择用药。
The 24-hour pH dynamic monitoring was used to observe the anti-reflux effect of cisapride and ranitidine in 21 cases of reflux esophageal disease. The effects of two drugs on gastric pH and anti-gastroesophageal reflux The relevance of flow (GER) effects. The results showed that the esophageal acid reflux index in both cisapride and ranitidine groups was lower than before treatment, and there was no significant difference in descending index between the two groups (P> 0.05). The cisapride group had no effect on the intragastric pH. The ranitidine group could reduce the total time (%), the mean pH and the median pH in the stomach by pH <1, pH <2 and pH <3, The difference was significant (P <0.01). The effect of cisapride and ranitidine on gastric pH had no correlation with esophageal acid reflux index (r = -0.436 and -0.341, all P> 0.05). Studies have shown that both cisapride and ranitidine have a true anti-GER effect, comparable efficacy but different mechanism of action, the clinical should choose the appropriate medication.