目的探讨大剂量阿托伐他汀对急性脑梗死患者颈动脉粥样斑块的影响。方法80例入选患者被随机分成Ⅰ组(10mg阿托伐他汀组)和Ⅱ组(40mg阿托伐他汀组),各40例。治疗8周前后,详细记录两组颈动脉斑块的部位、数目、性质、面积、内膜-中层厚度(IMT);血TC、TG、HDL-C、LDL-C、hs-CRP值。结果8周后Ⅱ组斑块面积缩小、软斑及混合斑数量减小I、MT及hs-CRP减少有显著性意义(P<0.05),Ⅰ组变化无显著性差异;两组治疗后TC、LDL-C显著性降低,但组间比较差异无显著性。结论大剂量阿托伐他汀能在短期内低颈动脉内膜厚度、减少斑块面积,稳定斑块,减少炎症反应。 Objective To investigate the effect of high-dose atorvastatin on carotid artery plaque in patients with acute cerebral infarction. Methods Eighty patients were randomly divided into group Ⅰ (10 mg atorvastatin group) and group Ⅱ (40 mg atorvastatin group), 40 cases in each group. The location, number, nature, area, intima-media thickness (IMT), blood TC, TG, HDL-C, LDL-C and hs-CRP of carotid plaque in both groups were recorded before and 8 weeks after treatment. Results After 8 weeks, the area of ​​plaque in group Ⅱ was decreased, the number of plaque and mixed plaque was decreased, the reduction of MT and hs-CRP was significant (P <0.05), and there was no significant difference in group Ⅰ after treatment , LDL-C significantly reduced, but no significant difference between groups. Conclusions High-dose atorvastatin can reduce the carotid intima-media thickness in a short period, reduce plaque area, stabilize plaque and reduce inflammation.