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研究响应面法对番茄红素β-环糊精包合物制备工艺的优化。以番茄红素结晶为试验原料,在单因素试验的基础上,以番茄红素结晶与β-环糊精饱和溶液比、包埋时间、包埋温度为自变量,番茄红素的包埋率为响应值,采用Box-Behnken试验设计,利用响应面分析法对番茄红素β-环糊精包埋工艺进行优化。结果表明,最佳工艺条件为番茄红素结晶:β-环糊精饱和溶液1.4∶1(mg/mL)、包合温度49℃、包合时间70min。在此条件下,β-环糊精包合番茄红素的包埋率的预测值为92.10%,验证值最高达91.04%。
Optimization of the Preparation of Lycopene β - Cyclodextrin Inclusion Complexes by Response Surface Methodology. Lycopene crystallization as the experimental raw material, on the basis of single factor test, with lycopene crystallization and β-cyclodextrin saturated solution ratio, embedding time, embedding temperature as independent variables, lycopene embedding rate In response, the Box-Behnken design was used to optimize lycopene β-cyclodextrin embedding by response surface methodology. The results showed that the optimum conditions were lycopene crystallization: β-cyclodextrin saturated solution 1.4:1 (mg / mL), Inclusion temperature 49 ℃, Inclusion time 70min. Under these conditions, the predicted value of inclusion rate of β-cyclodextrin inclusion lycopene was 92.10% and the validation value was up to 91.04%.