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醌霉素是一类由链霉菌产生的环状寡肽抗生素,结构上拥有一对特征性喹喔啉-2-甲酰基或3-羟基喹啉-2-甲酰基单元.醌霉素选择性插入到DNA分子的碱基对之间,抑制DNA的复制和转录,因而具有良好的肿瘤抑制活性.综述了近十年来醌霉素家族抗生素的生物合成研究进展,通过比较醌霉素不同代表成员的基因簇,归纳这些化合物与其它类型天然产物生物合成以及色氨酸分解代谢中的相似反应,并剖析催化这些反应的酶的功能特性,揭示了醌霉素的化学结构特征和其不同成员之间结构差异的形成原因.在此基础上,还介绍了在异源宿主大肠杆菌中用组合生物合成的方法产生醌霉素类非天然的天然产物的范例,展示了该类抗生素工业化生产的潜力.
Quinomycin is a class of cyclic oligopeptide antibiotics that are produced by Streptomyces and structurally possess a pair of characteristic quinoxaline-2-formyl or 3-hydroxyquinoline-2-formyl units. Quinomycin selectivity Inserted into the base pairs of DNA molecules to inhibit DNA replication and transcription, and thus has a good tumor suppressor activity.Review of the past decade the progress of biosynthesis of quinone family antibiotics, by comparing the different representatives of quinone , Summarizing the similar reactions of these compounds with other types of natural product biosynthesis and tryptophan catabolism and analyzing the functional properties of the enzymes that catalyze these reactions reveal the chemical structural features of quinuclidine and its different members On the basis of this, also introduced the use of combinatorial biosynthesis in heterologous host E. coli produced non-natural citrinin natural product example shows the potential of industrial production of antibiotics .