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目的:探讨血清尿酸水平与急性脑梗死患者颈动脉粥样硬化斑块的相关性,分析其临床价值。方法:回顾性分析2011-03-2014-05我院收治的451例急性脑梗死患者的临床资料,根据有无发生颈动脉粥样硬化分为脑梗死无颈动脉粥样硬化组(n=85)与有颈动脉粥样硬化组(n=366),组间进行血清尿酸水平比较;根据有无形成动脉粥样硬化和硬化大小分为脑梗死无颈动脉粥样硬化组(n=85)、颈动脉粥样内中膜增厚组(n=46)、颈动脉粥样斑块形成组(n=320),组间进行血清尿酸水平比较;根据有无形成颈动脉斑块和稳定性程度分为脑梗死无颈动脉斑块组(n=120)、稳定颈动脉斑块组(n=146)、不稳定颈动脉斑块组(n=185),组间进行血清尿酸水平比较;按有无形成颈动脉斑块分为有颈动脉斑块组(n=331)和无颈动脉斑块组(n=120),组间进行一般资料比较;按尿酸水平分为正常尿酸血症组(n=66)、高尿酸血症组(n=385),组间进行颈动脉斑块发生情况比较;按尿酸水平的四分位数分为4个数组,组间进行颈动脉斑块发生情况比较。结果:脑梗死有颈动脉粥样硬化组的血清尿酸水平显著高于脑梗死无颈动脉粥样硬化组(P<0.05);脑梗死无颈动脉粥样硬化组、内中膜增厚组及斑块形成组血清尿酸水平比较,差异无统计学意义;脑梗死无斑块组和稳定斑块组的血清尿酸水平显著低于不稳定斑块组(P<0.05);脑梗死无斑块组和稳定斑块组间血清尿酸水平比较,差异无统计学意义;有颈动脉斑块组和无颈动脉斑块组尿酸、纤维蛋白原、同型半胱氨酸、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇比较,差异均无统计学意义,而年龄、糖化血红蛋白、脂蛋白a比较,差异有统计学意义(P<0.05);正常尿酸血症组和高尿酸血症组颈动脉斑块的发生情况比较,差异无统计学意义;尿酸水平的四分位数分为4个数组间的颈动脉斑块的发生情况比较,差异均无统计学意义。结论:急性脑梗死患者的颈动脉粥样硬化斑块与血清尿酸水平没有明显的联系,稳定颈动脉斑块和无颈动脉斑块的颈动脉样硬化的血清尿酸水平明显优于不稳定颈动脉斑块者。
Objective: To investigate the correlation between serum uric acid level and carotid atherosclerotic plaque in patients with acute cerebral infarction and analyze its clinical value. Methods: The clinical data of 451 patients with acute cerebral infarction admitted to our hospital from March 2011 to April 2014 were retrospectively analyzed. According to the presence or absence of carotid atherosclerosis, there was no carotid atherosclerosis group (n = 85 ) And carotid atherosclerosis group (n = 366) .Serum uric acid levels were compared between groups. According to the presence or absence of atherosclerosis and sclerosis, there was no carotid atherosclerosis group (n = 85) , Carotid intima-media thickening group (n = 46) and carotid artery atherosclerotic plaque formation group (n = 320) .Serum uric acid levels were compared between groups. According to the presence or absence of carotid artery plaque and stability The degree of cerebral infarction was divided into three groups: carotid artery plaque group (n = 120), stable carotid artery plaque group (n = 146) and unstable carotid artery plaque group (n = 185) Carotid plaques were divided into carotid artery plaque group (n = 331) and carotid artery plaque group (n = 120) according to the presence or absence of carotid artery plaque. The general data were compared between groups. According to uric acid level, they were divided into normal uric acid Group (n = 66) and hyperuricemia group (n = 385). Carotid plaque was compared among groups. According to the quartiles of uric acid level, they were divided into 4 groups. Carotid plaque Block the situation occurs. Results: The levels of serum uric acid in patients with carotid atherosclerosis were significantly higher than those without carotid atherosclerosis in cerebral infarction (P <0.05). There was no significant difference in the incidence of carotid atherosclerosis, intima - media thickness, There was no significant difference in serum uric acid levels between the plaque formation group and the non-plaque group and the stable plaque group (P <0.05). No plaque group And stable plaque group serum uric acid levels, the difference was not statistically significant; carotid plaque group and no carotid plaque group uric acid, fibrinogen, homocysteine, high-density lipoprotein cholesterol, low density (P <0.05). There was no significant difference in lipoprotein cholesterol between the two groups (P <0.05). There were significant differences in age, glycosylated hemoglobin and lipoprotein (P <0.05) between normal uric acid group and hyperuricemia group The difference was not statistically significant; the quartile of uric acid level was divided into 4 groups of carotid plaques compared between the occurrence of the difference was not statistically significant. CONCLUSIONS: Carotid atherosclerotic plaques in patients with acute cerebral infarction are not significantly associated with serum uric acid levels. Serum uric acid levels in carotid atherosclerotic plaques stabilized with carotid plaques and carotid artery plaques were significantly better than those with unstable carotid arteries Plaque who.