Biomanufacturing,which uses renewable resources as raw materials and uses biological processes to pro-duce energy and chemicals,has long been regarded as a production model that replaces the unsustain-able fossil economy.The construction of non-natural and efficient biosynthesis routes of chemicals is an important goal of green biomanufacturing.Traditional methods that rely on experience are difficult to support the realization of this goal.However,with the rapid development of information technology,the intelligence of biomanufacturing has brought hope to achieve this goal.Retrobiosynthesis and com-putational enzyme design,as two of the main technologies in intelligent biomanufacturing,have devel-oped rapidly in recent years and have made great achievements and some representative works have demonstrated the great value that the integration of the two fields may bring.To achieve the final inte-gration of the two fields,it is necessary to examine the information,methods and tools from a bird\'s-eye view,and to find a feasible idea and solution for establishing a connection point.For this purpose,this article briefly reviewed the main ideas,methods and tools of the two fields,and put forward views on how to achieve the integration of the two fields.