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通过氯代环戊烯和相应的嘧啶碱基缩合,再环氧化和开环得到了5′-去羟甲基碳环核苷类似物。所合成化合物经体外L_(1210)和肝癌细胞筛选,并用2215细胞株进行抗乙肝病毒筛选,均未发现有意义的活性。
The 5’-demethylolcyclic nucleoside analogue is obtained by condensation of chlorocyclopentene and the corresponding pyrimidine base, followed by epoxidation and ring opening. The synthesized compounds were screened by L1212 cells in vitro and hepatoma cells, and 2215 cells were screened for anti-HBV, and no significant activity was found.