Synthesis and Fungicidal Activities of 2-Alkylthio-5-(3,4,5-tribenzyloxyphenyl)-l, 3,4-oxadiazoles

来源 :Chinese Chemical Letters | 被引量 : 0次 | 上传用户:gzliuwei2008
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Ten novel 2-alkylthio-5-(3, 4, 5-tribenzyloxyphenyl)-1, 3, 4-oxadiazole derivatives (5a-j) were synthesized from methyl 3, 4, 5-trihydroxybenzoate by etherification, hydrazidation, cyclization and thioetherification reactions. The structures of 5a-j were confirmed by 1HNMR, MS spectra and elemental analysis. The results indicated that most of the compounds 5 exhibited good fungicidal activities. The activity of 5h is higher than 90% against Fusarium oxysporum and Botrytis cinereapers in 50 mg/L. Ten novel 2-alkylthio-5- (3,4,5-tribenzyloxyphenyl) -1,3,4-oxadiazole derivatives (5a-j) were synthesized from methyl 3,4,5-trihydroxybenzoate by etherification, hydrazidation, cyclization and thioetherification The structures of 5a-j were confirmed by 1HNMR, MS spectra and elemental analysis. The results indicate that most compounds 5 exhibit good fungicidal activities. The activity of 5h is higher than 90% against Fusarium oxysporum and Botrytis cinereapers in 50 mg / L.
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