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目的探讨上海地区非酒精性脂肪性肝炎(NASH)患者体质类型分布特点,为中医药防治NASH提供理论依据。方法通过问卷调查对已诊断为NASH的450例患者进行中医体质分析,同时观察其在体重指数、腰臀比率、血脂和血清学指标等方面不同特点。结果 450例NASH患者的主要体质类型分别是气虚质(单纯气虚质和兼夹体质中气虚质的总和,下同)为116例(25.78%),阴虚质为114例(25.33%),痰湿质为162例(36%),气郁质98例(23.79%);BMI和ALT之间密切相关(r值为0.101);随着BMI的增加,ALT呈上升趋势;相反,随着WHR的增加,TC呈下降趋势,TC与TG呈正相关(P<0.05),并与NASH的发生密切相关。结论 NASH患者的体质类型主要以痰湿质、气虚质、阴虚质、气郁质为主,其中兼夹体质占有一定比例。
Objective To investigate the distribution of physique types in patients with non-alcoholic steatohepatitis (NASH) in Shanghai and to provide a theoretical basis for the prevention and treatment of NASH by Chinese medicine. Methods A total of 450 patients with NASH who had been diagnosed as NASH were investigated by questionnaire and their differences in body mass index, waist-to-hip ratio, blood lipids and serological parameters were observed. Results The main physical types of 450 patients with NASH were 116 (25.78%) and 114 (25.33%) with deficiency of qi and qi deficiency (sputum and qi deficiency) There were 162 (36%) wet masses and 98 (23.79%) patients with wet masses. The correlation between BMI and ALT was significant (r = 0.101). ALT increased with increasing BMI. On the contrary, (P <0.05). The TC was in a descending trend. The TC was positively correlated with TG (P <0.05), and was closely related to the occurrence of NASH. Conclusion The main types of physical constitution of NASH patients are phlegm-dampness, qi deficiency, yin deficiency and qi deficiency, of which physique occupies a certain proportion.