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甾族抗生素是具有梭链孢烷(Fusida-ne)骨架的羧链孢酸(Fusidic acid)类化合物和其他一些甾体衍生物,包括多孔蕈酸型三萜甾类,氮杂甾类等有抗菌活性和细胞毒作用的物质。 羧链孢酸类化合物是以一些真菌的培养物中分离出来的,甾族抗生素的第一个成员是1943年发现的蜡黄酸(Helvolic acid)。最主要的成员梭链孢酸则是1963年发现的,从化学结构来看。此类抗生素含有共同的羧链孢烷骨架(图1),C_(17)位侧链有α,β-不饱和羧酸,C_(16)位有-β-(16,21-顺式)一定向的乙酰氧基因。
Steroid antibiotics are Fusidic acid compounds having Fusida-ne skeleton and other steroid derivatives, including those having the property of a multi-fungal type triterpene steroid, an azasteroid and the like Antibacterial activity and cytotoxic substances. Carbosulants are isolated from cultures of some fungi. The first member of the steroid antibiotic was Helvolic acid, which was discovered in 1943. The main member of Fusidic acid was discovered in 1963, from the chemical structure point of view. Such antibiotics contain a common carboxalphane backbone (Figure 1), an α, β-unsaturated carboxylic acid on the C 17 side and a -β- (16,21-cis) A directional acetoxygen.