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机体对电离辐射反应非常复杂,受许多分子调节途径控制,p53就是这样的应激途径之一。已经知道它涉及100多个基因的活动,这些应激基因活动具有某种细胞特异性,DNA芯片技术可以完整地研究整个细胞或器官全部基因变化,可以通过基因分析发现对电离辐射的基因反应差异,从而建立一种新的分子放射生物学方法。应用该技术已经初步发现一些新的辐射反应基因活动,在不同基因背景这些基因活动变化很大,提示生物细胞对环境有害因素反应的复杂性及其在正常组织和肿瘤分化增殖过程中基因调控的重要意义,这种技术也可能成为肿瘤治疗和其他环境毒理研究的检测和预测方法。
The body’s response to ionizing radiation is complex and controlled by many molecular regulators. P53 is one of such stress pathways. It has been known that it involves more than 100 gene activities, these stress gene activity has a cell-specific, DNA chip technology can be a complete study of the entire cell or organ gene changes can be found by genetic analysis of ionizing radiation gene response differences , Thus establishing a new molecular radiobiological method. The application of the technology has initially found some new radiation response gene activity, which varies greatly in different genetic backgrounds, suggesting the complexity of response of biological cells to environmental harmful factors and their gene regulation in normal tissues and tumor differentiation and proliferation Significantly, this technique may also be a detection and prediction method for oncology treatments and other environmental toxicological studies.