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新化合物ｌ２（６甲氧基２萘） 丙酸（ 对乙酰氨基） 酚酯（ Ⅱ） 是根据萘普生前药结构合成的衍生物，本文报道该化合物的抗炎镇痛作用。采用抗炎模型二甲苯致小鼠耳炎、角叉菜胶引起的小鼠足肿胀、大鼠肉芽肿胀和镇痛模型醋酸引起小鼠扭体测定了的化合物抗炎镇痛作用。结果表明：该化合物能明显抑制二甲苯引起的小鼠耳炎和角叉菜胶引起的小鼠足肿胀，连续８ ｄ 给药能明显抑制大鼠的肉芽肿胀；同时该化合物还能减少醋酸引起的小鼠扭体数，表现出较好的抗炎镇痛效果。
The new compound l 2 (6 methoxy 2 naphthalene) propionic acid (p-acetamido) phenol ester (Ⅱ) is based on the structural derivatives of naproxen drug precursor derivatives reported in this article anti-inflammatory analgesic effect. The anti-inflammatory and analgesic effect of the compound was tested by mouse writhing induced by anti-inflammatory model xylene-induced mouse otitis, carrageenan-induced foot swelling in mice, rat granulomatous swelling and analgesia model. The results showed that the compound can significantly inhibit xylene-induced otitis media and carrageenan-induced foot swelling in mice, administration of 8 consecutive days can significantly inhibit rat granulomatous swelling; at the same time the compound can also reduce acetic acid caused The number of mice writhing, showing better anti-inflammatory analgesic effect.