在Bhatnagar和Shrivastava二氏和Meyer氏的研究中,首先注意到对鼠疫杆菌(Yersinia pestis)的细胞免疫反应。此后,显然本病的发展取决于网状内皮系统的单核吞噬细胞是否活化。某些鼠疫杆菌菌株含有一种免疫性高的和抗吞噬的被膜抗原F_1,但体液对这种抗原的反应产生的抗体使鼠疫 In the Bhatnagar and Shrivastava II and Meyer studies, the cellular immune response to Yersinia pestis was first noted. Since then, it is clear that the development of this disease depends on the reticuloendothelial system of mononuclear phagocytes is activated. Some Yersinia strains contain an immunogenic and anti-phagocytic membrane antigen, F_1, but the antibody produced by the humoral response to this antigen causes plague