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疟疾疫苗的研究已集中到感染裂殖体的红细胞或游离裂殖子的抗原上,这些抗原能导致产生阻断红细胞期原虫发育的抗体或者集中在子孢子的抗原上,这一抗原可引起产生阻止原虫进入肝细胞的抗体。最近的研究表明,与裂殖子和感染裂殖体红细胞表面分子量约为200,000的蛋白质起反应的抗体能阻断红细胞内原虫的裂体增殖。用DNA重组技术,对编码大的抗原性复杂的多肽基进行克隆虽是困难的,但已有人做到了这点。 Cochrane等(1980)用少量减毒的子孢子进行免疫,能得到对以后攻击的保护免疫力。这种免疫力,有种的而不是株的特异性,
Studies of malaria vaccines have focused on the antigens of schizonts that attack red blood cells or free merozoites that can lead to the production of antibodies that block the development of erythrocytic protozoa or to the sporozoite antigens that can cause production Antibodies that prevent protozoa from entering the liver cells. Recent studies have shown that antibodies that react with merozoites and proteins with a molecular weight of about 200,000 on the surface of red blood cells of schizonts can block the proliferation of erythrocytic protozoan. It has been difficult to clone a large, antigenically complex polypeptide base using DNA recombination techniques, but this has already been done. Cochrane et al. (1980) immunized with a small amount of attenuated sporozoites gave protection against subsequent challenge. This kind of immunity, kind of rather than strain specificity,