论文部分内容阅读
目的总结慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者院外用药情况,并分析其院外用药情况、痰真菌检出率以及激素不良反应发生率的变化。方法调查2011年1 6月住院的161例COPD患者院外用药情况,将其分为遵医嘱使用糖皮质激素组(A组,包括口服和吸入激素)、使用非准字号药物组(B组)和未使用以上两种药物组(C组),对各组的痰真菌检出率进行统计学分析,并对A、B组激素不良反应的发生率进行分析。再将现阶段的调查结果与2006年同样研究结果进行比较。结果 161例患者中使用口服糖皮质激素6例,使用吸入激素29例,使用非准字号药物32例,未使用以上两种药物94例。痰真菌检出率情况:B组检出率为62.5%,明显高于A组的17.14%、C组的27.66%;组间比较有统计学意义(P<0.001)。B组的药物不良反应发生率为37.5%;A组中口服激素发生率为50%,而使用吸入激素发生率为0%。与2006年同样研究结果比较,B组患者的比例明显下降,A组患者明显增多。结论使用非准字号药物的患者,真菌感染的危险性及激素不良反应的发生率较高,健康教育对于减少这些不良现象的发生发挥了重要作用。
Objective To summarize the outpatient medication in patients with chronic obstructive pulmonary disease (COPD) and analyze the changes of the drug use in hospital, the detection rate of sputum fungi and the incidence of adverse reactions. Methods A total of 161 COPD patients admitted to hospital from January to June in 2011 were enrolled in the study. The patients were divided into obstetrics and gynecology patients using glucocorticoid (group A, including oral and inhaled corticosteroids), non-quasi-drug group (group B) and The above two groups of drugs were not used (group C), the detection rate of sputum fungi in each group were statistically analyzed, and the incidence of adverse reactions in group A and group B were analyzed. Then the current survey results compared with the same research results in 2006. Results In 161 patients, oral glucocorticoids were used in 6 cases, inhaled hormones in 29 cases, non-quasi-type drugs in 32 cases and non-use of the above two drugs in 94 cases. The detection rate of sputum fungi: The detection rate of group B was 62.5%, which was significantly higher than that of group A (17.14%) and group C (27.66%). There was significant difference between groups (P <0.001). The incidence of adverse drug reactions in group B was 37.5%; in group A, the incidence of oral hormones was 50%, while that of inhaled hormones was 0%. Compared with the same results in 2006, the proportion of patients in group B decreased significantly, and the patients in group A increased significantly. Conclusion In patients with non-quasi-hypertensive drugs, the risk of fungal infection and the incidence of adverse reactions to steroids are high, and health education plays an important role in reducing these adverse phenomena.