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研究难治性肺结核的治疗及为各种基础病伴发结核及耐多种药的结核病人提供有效的治疗。采用乳酸左氧氟沙星为基础药物,根据病人具体情况选用下列药品中的2～3 种:INH、SM、PAS、EMB、PSN、RFP。对27 例患者采用以上方案强化治疗2 个月后,依据疗效确立以INH 为基础药加上同一方案中的1～2种药物进行巩固治疗。结果27 例患者临床控制16 例,显效7 例,进步3 例,有效率达85% 。提示综合医院就诊的肺结核病患者中复治的和耐药的病例日益增加,基础病伴发肺结核和机体免疫和脏器功能(肝功能受损)的变化,以及其他用药的影响等,使临床上常规用药治疗肺结核棘手。本组27 例难治性肺结核经乳酸左氧氟沙星联合强化治疗取得较好疗效,且肝损害作用小,为临床治疗难治性肺结核提供了新的方案
To study the treatment of refractory pulmonary tuberculosis and tuberculosis and multi-drug resistant TB patients with various underlying diseases. Levofloxacin lactate-based drugs, according to the specific circumstances of patients with the following drugs in the selection of 2 to 3: INH, SM, PAS, EMB, PSN, RFP. 27 patients with intensive treatment of the above program 2 months later, based on the efficacy established with INH-based drugs plus the same program of 1 or 2 drugs for consolidation therapy. Results Of the 27 patients, 16 were controlled clinically, 7 were markedly effective and 3 were improved. The effective rate was 85%. Prompt general hospital tuberculosis patients with retreatment and resistant cases are increasing, the basic disease associated with pulmonary tuberculosis and immune and organ function (impaired liver function) changes, as well as the impact of other drugs, the clinical On the conventional treatment of tuberculosis thorny. The group of 27 cases of refractory pulmonary tuberculosis by levofloxacin lactate combined with intensive treatment achieved good effect, and the role of small liver damage, for the clinical treatment of refractory tuberculosis provides a new program