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上皮生长因子是一种多肽类物质，它有抑制体细胞分泌胃酸，增加胃粘膜的血流量，促进受损的胃粘膜细胞再生的作用。实验证实：一定剂量的ＥＧＦ经皮下给药有保护胃粘膜的作用。而直接的灌注并无这种保护作用。因此给药途径是十分重要的决定因素之一。推测其原因，应激时交感神经的兴奋，引起消化系统的内脏血管收缩，粘膜的血流量减少，胃的缺血缺氧是导致粘膜损伤的重要原因，ＥＧＦ因为增加了胃粘膜的血流量；增强了胃粘膜细胞抵抗胃酸的侵蚀能力；而根据胃酸分泌量与胃泌素血浓度同步下降的现象，可以认为其抑制胃酸的作用是通过抑制胃泌素的分泌而致的。ＥＧＦ作为预防应激性溃疡的药物，在临床上有良好的应用前景。
Epithelial growth factor is a polypeptide substance that inhibits somatic cell secretion of gastric acid, increases gastric mucosal blood flow, and promotes the regeneration of damaged gastric mucosal cells. Experiments confirmed that: a dose of EGF subcutaneously to protect the role of gastric mucosa. Direct perfusion does not have this protective effect. Therefore, the route of administration is one of the most important determinants. It is speculated that the reason, the excitement of sympathetic stress, causing visceral vasoconstriction of the digestive system, mucosal blood flow decreased, gastric ischemia and hypoxia is an important cause of mucosal injury, EGF because of increased gastric mucosal blood flow; Enhance gastric mucosal cell resistance to gastric acid erosion; and according to gastric acid secretion and gastrin blood concentration decreased synchronously, it can be considered that the role of inhibition of gastric acid by inhibiting the secretion of gastrin caused. EGF as a prevention of stress ulcer drugs, has a good clinical application.