统计了１１０族同源蛋白质的多重结构联配结果，得到了局部环境依赖的氨基酸相似分数表。按此表可实施快速和优质的蛋白质结构刚性叠加，用于蛋白质工程。跟目前最好的遗传算法比较，此法可达到相同的品质（尽可能多的拓扑等价残基对和尽可能小的均方根距离），但ＣＰＵ时间降了１个到２个数量级，对大蛋白更为明显。 The results of the multiple structure alignment of the 110 family homologous proteins were statistically analyzed, and the amino acid similarity score table of local environment dependence was obtained. Click here to implement a fast and high-quality rigid stack of protein structures for protein engineering. This method achieves the same quality (as much as possible topological equivalent residue pair and as small a rms distance as possible) compared to the best genetic algorithms available today, but CPU time drops by one to two orders of magnitude, Bigger protein is more obvious.