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【目的】探讨亚低温治疗对重症高血压脑出血患者血清白介素6(IL-6)及 C 反应蛋白(CRP)水平的影响。【方法】选取2011年1月至2015年6月本院收治的118例重症高血压脑出血患者。采用随机数字表法将其分为观察组和对照组，每组各59例。两组患者均行开颅血肿清除+去骨瓣减压术，术后均给予常规治疗，观察组辅以亚低温治疗。治疗前及治疗 d1、d3、d7检测两组血清 IL-6及 CRP 水平；治疗30 d 进行疗效评价；治疗3个月后进行格拉斯哥预后分级(GOS)。【结果】两组血清 IL-6及 CRP 水平比较均无显著性差异(P >0.05)，观察组患者治疗后血清 IL-6及 CRP 水平均显著降低(P <0.05)；且 d3、d7血清 IL-6及 CRP 水平均显著低于对照组，差异具有统计学意义(P <0.05)；对照组治疗 d1、d7血清 CRP 水平显著低于治疗前，差异具有统计学意义(P <0.05)。观察组总有效率为69.49%显著高于对照组50.85%，差异有显著性(P 0.05).After treatment,the level of IL-6 and CRP significantly decreased and was significantly lower than that of the control group at 3 and 7 d (P <0.05). The total effective of the observation group and the control group were 69.49% and 50.85%,with significant difference (P <0.05).The prognosis of the observation group was significantly better than that of the control group (P < 0.05 ).[Conclusion]Hypothermia treatment on patients with severe hypertensive intracerebral hemorrhage could decrease the serum IL-6 and CRP level and improve the prognosis.