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心房颤动的(简称房颤)发生机制一直是医学界研究的热点与难点。近年来,各种学说机制并存,其中电生理机制学说多见。分布于心肌细胞上与生命活动密切相关的离子通道基因单核苷酸多态性可致离子通道重构,从而影响心房肌细胞动作电位,导致心房电重构,进而增加房颤的易患性。其中以钾离子通道基因单核苷酸多态性与房颤发生的相关性研究较为深入。
The mechanism of atrial fibrillation (referred to as atrial fibrillation) has been a hot and difficult point in medical research. In recent years, a variety of doctrine mechanisms co-exist, including electrophysiological mechanisms theory more common. Single nucleotide polymorphisms of ion channel genes, which are closely related to life activities, are located on cardiomyocytes, which lead to the remodeling of ion channels and thus affect the action potentials of atrial myocytes, resulting in atrial electrical remodeling and thus increased susceptibility to atrial fibrillation . Among them, the correlation between single nucleotide polymorphism of potassium channel and occurrence of atrial fibrillation is more in-depth.