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甲硫达嗪是一种带有哌啶侧链的苯并噻嗪类精神治疗药。它的诱变作用和断裂作用在植物系和动物系一直进行研究。就遗传毒性而言,一种化学药物对不同物种的作用也许是不同的。因此,在本文中我们研究人体内甲硫达嗪对淋巴细胞培养物中人类染色体的作用。本研究筛选了印度海得拉巴市智力保护学校20～55岁之间的精神病人。他们每天接受剂量为50～400mg 的甲硫达嗪的治疗,疗程为4周。选择两个对照组:(1)新诊断的未接受治疗的精神病人;(2)一般群体中正常健康的个体。血液培养采用Moor-
Methylthiazide is a benzothiazine psychotropic drug with a side chain of piperidine. Its mutagenesis and cleavage have been studied both in plant and animal families. In terms of genotoxicity, the effect of a chemical on different species may be different. Therefore, in this paper, we investigate the effects of metothiadine on human chromosomes in lymphocyte cultures in humans. This study screened mental patients between 20 and 55 years of age in Hyderabad Intelligence Protection School in India. They received daily doses of 50 to 400 mg of methotadine for a period of 4 weeks. Two control groups were selected: (1) newly diagnosed untreated mental patients; (2) normal healthy individuals in the general population. Blood culture using Moor-