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为探讨八氯二丙醚的致突变性和致畸性，采用Ａｍｅｓ试验、小鼠骨髓嗜多染红细胞微核试验、传统致畸试验进行了检测。结果发现：Ａｍｅｓ试验中仅有两个浓度的回变菌落数为阴性对照的两倍以上，但无剂量反应关系；致畸试验在８０，３２０和１６００ｍｇ／ｋｇ的染毒剂量条件下，没有发现明显的致畸作用。但１６００ｍｇ／ｋｇ的剂量对孕鼠和胎鼠都有一定的毒性作用。低剂量组胎鼠的体重和身长及尾长均高于阴性对照组。经统计学检验差异均有显著性（Ｐ＜０．０１）。
To investigate the mutagenicity and teratogenicity of octachlorodipropyl ether, Ames test, micronucleus test of mouse bone marrow polychromatic erythrocytes and conventional teratogenicity test were carried out. The results showed that: only two concentrations of Ames test back to the number of colony-negative control more than twice, but no dose-response relationship; teratogenicity test at doses of 80,320 and 1600mg / kg did not find Significant teratogenic effects. However, 1600mg / kg dose of pregnant rats and fetal rats have some toxic effects. The body weight, body length and tail length of low dose group were higher than that of negative control group. The statistical test showed significant differences (P <0.01).