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无环鸟苷是抗病毒药物,对单疱病毒组(除巨细胞病毒外)具有较强活性和特异性。无环鸟苷对无感染的细胞毒性很小。本文研究了结膜下注射及局部点眼后不同时间眼内药物浓度。材料及方法:共用47只新西兰白兔,分成3组。 A组:每只兔的一眼球结膜下注射25mg无环鸟苷钠盐[0.5ml含25mg/ml(50g/l)],注射后1、3、5及24小时抽取
Acyclovir is an antiviral drug that has strong activity and specificity for the herpes simplex virus group (except cytomegalovirus). Acyclovir cytotoxicity to non-infected small. This article investigates the intraocular drug concentrations at subconjunctival injections and at different times after the local eye-spotting. Materials and Methods: A total of 47 New Zealand white rabbits were divided into 3 groups. Group A: A subconjunctival injection of 25mg acyclovir sodium [0.5ml containing 25mg / ml (50g / l)] was given to one eye of each rabbit, and the samples were taken at 1, 3, 5 and 24 hours after the injection