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高脂血症是中、老年人常见病之一,近年来随着临床药理学研究不断发展,临床上发现一些老药用于治疗高脂血症,收到显著疗效。现根据有关文献资料,将其综述如下。 一、甲硝唑 何家生等报道对11例高脂血症病人,胆固醇在6.2mmol以上或甘油三酯在1.47mmol以上。服用甲硝唑(灭滴灵),第一周1800mg/d,饭后3次分服;第二周开始减量为1200mg/d。服药后第一周末,全部病例的总脂、胆固醇及甘油三酯均有显著降低。总脂从平均7.01g/L降低到5.0g/L。下降29％(P<0.01);胆固醇从平均7.1mmol降到5.2mmol,下降27％(P<0.01);甘油三
Hyperlipidemia is one of the most common diseases in the elderly. In recent years, with the continuous development of clinical pharmacology research, some old drugs are found clinically for the treatment of hyperlipidemia and have received a significant effect. Now based on the literature, will be summarized as follows. First, metronidazole He Jiasheng and other reports of 11 cases of hyperlipidemia patients, cholesterol at 6.2mmol or more triglycerides in more than 1.47mmol. Taking metronidazole (metronidazole), the first week of 1800mg / d, 3 times after meals points; the first two weeks reduced to 1200mg / d. On the first weekend after taking the medication, total lipid, cholesterol, and triglycerides were significantly reduced in all cases. The total fat decreased from an average of 7.01 g / L to 5.0 g / L. Decreased by 29% (P <0.01), cholesterol decreased from average 7.1 mmol to 5.2 mmol, decreased by 27% (P <0.01)