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目的:探讨妊娠期急性脂肪肝诊治措施与注意事项。方法:将2013年1月~2016年1月我院收治的14例妊娠期急性脂肪肝患者纳入到本组研究中,在入院后第一时间进行相关检查,在确诊后为患者输注凝血物质,包括冷沉淀、冰冻白浆、纤维蛋白原、凝血酸后复合物、维生素K1,并予以抗炎、退黄、护肝等对症治疗的方式。对本组患者的临床资料进行回顾性分析。结果:14例患者中,1例患者在术后6d临床体征趋于平稳,9例患者产后10~20d体征平稳出院,4例患者术后病情恶化,治疗无效死亡。在新生儿中,3例死胎,3例重度窒息。结论:妊娠期急性脂肪肝是妊娠期少见的以可逆性肝衰为主的严重并发症,对于该种疾病,需要及时确诊,终止妊娠,进行综合性的治疗,这是提高产妇与围产儿生存率的主要措施。
Objective: To investigate the diagnosis and treatment of acute fatty liver during pregnancy and precautions. Methods: From January 2013 to January 2016, 14 cases of acute fatty liver during pregnancy were enrolled in this study. The patients were followed up for the first time after admission, and after the diagnosis, coagulation substance , Including cold precipitation, frozen white pulp, fibrinogen, tranexamic acid complex, vitamin K1, and anti-inflammatory, yellow, liver and other symptomatic treatment. The clinical data of this group were retrospectively analyzed. Results: Among the 14 patients, one patient had stable clinical signs on the 6th day after operation. Nine patients were discharged smoothly from 10 to 20 days postpartum. Four patients were exacerbated after operation and died of ineffective treatment. In newborns, 3 stillbirths and 3 severe asphyxiation. Conclusions: Acute fatty liver during pregnancy is a rare severe reversible liver failure in pregnancy. For this disease, timely diagnosis, termination of pregnancy and comprehensive treatment are necessary to improve the survival of pregnant women and perinatal children Rate of the main measures.