病毒的某些突变可改变其多肽序列,从而改变这些多肽的抗原表位。感染这些突变株后,由于病毒丧失了病毒特异性CTL的识别结点,从而逃逸了机体抗病毒免疫,导致病毒的持续性感染。淋巴细胞脉络丛脑膜炎病毒(LCMV)是非裂殖性的RNA病毒。通常,小鼠感染LCMV后,可诱生保护性CTL反应,清除病毒及诱生免疫病理改变。然而,感染伴有CTL识别位点突变的LCMV后,也可能改变病毒-宿主反应。 Certain mutations in the virus alter their polypeptide sequences, altering the epitope of these polypeptides. Infection with these mutants escapes the body’s anti-viral immunity, resulting in a persistent infection with the virus, as the virus loses recognition of virus-specific CTLs. Lymphocytic choriomeningitis virus (LCMV) is a non-schizotypic RNA virus. In general, mice infected with LCMV can induce a protective CTL response, clear the virus and induce immunopathological changes. However, infection with LCMV with a CTL recognition site mutation may also alter the virus-host response.