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本文以不同氟水平地区153名怀孕4个月以上的孕妇为对象研究氟对胎儿可能产生的影响。结果表明,随着孕妇尿氟水平的升高其胎儿羊水氟含量也升高,差异显著(p<0.01)。通过对29例胎儿股骨的光镜观察及3例扫描电镜的观察,发现孕妇尿氟、胎儿羊水氟水平高者有明显病理改变,主要表现为骨生成活跃且紊乱。病理改变与尿氟、羊水氟氟水平有关,当尿氟小于2.0mg/L、羊水氟小于0.03mg/L 无病理改变发生。尿氟水平低于3.5mg/L 组,病理改变率为17.39%,(4/23),高于7mg/L 组病理改变率为83.33%(5/6),两者差异显著(P=0.0055);羊水氟水平低于0.05mg/L 组病理改变率为8.3%(1/12),高于0.05mg/L 组为47.06(8/17),差异显著(p=0.0422)。研究结果提示,氟能经过胎盘进入胎儿体内且可用羊水氟水平反应胎儿受氟量的高低及判断能否受到影响,说明氟对人体的作用在胎儿时期即可发生,这为氟中毒的早期防治提供了依据。
In this paper, 153 pregnant women with more than 4 months pregnant in different fluoride levels were investigated for the possible effects of fluoride on the fetus. The results showed that with the increase of urinary fluoride levels in pregnant women, their fetal amniotic fluid fluorine content also increased, the difference was significant (p <0.01). Through the observation of 29 cases of fetal femur by light microscopy and 3 cases of scanning electron microscopy, found that urinary fluoride, fetal amniotic fluid fluoride levels in patients with significant pathological changes, mainly for the active and disorderly bone formation. Pathological changes and urinary fluoride, fluoride levels of amniotic fluid, when the urine fluoride is less than 2.0mg / L, amniotic fluid fluoride less than 0.03mg / L no pathological changes occur. The rate of pathological changes was 17.39% (4/23) in patients with urinary fluoride lower than 3.5mg / L, and 83.33% (5/6) higher than those in patients with 7mg / L of urinary fluoride. The difference was significant (P = 0.0055 ). The pathological change rate of amniotic fluid with fluoride level less than 0.05mg / L was 8.3% (1/12) and higher than 0.05mg / L group was 47.06 (8/17), the difference was significant (p = 0.0422). The results suggest that fluoride can enter the fetus through the placenta and amniotic fluid levels of fluoride can be used to reflect the fetus by the level of fluoride and determine whether the impact can be affected, indicating that the role of fluorine in the human body can occur in the fetus, which is early prevention and treatment of fluorosis Provided the basis.