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Esmonde及其同事报告了29例发病前曾经献血的亚急性海绵状脑病(CJD)患者,他们根据地理资料排除了本病传染的可能性,因为这些献血者在献血期间所居住的地区内CJD的发病率并未增加。但这种研究方法的潜在问题是不清楚在病程中或在潜伏期内什么时候发生了病毒血症,这与在应用人生长激素疗法时发生的医源性CJD观察结果大相径庭。由于接受输血往往是严重的疾病,因而存在着血脑屏障的紊乱,作者推测在CJD的病毒血症期间CJD病毒可达到神经系统。通过输血传递的可能性只能借助于对CJD患者所献的每一个血单位应用
Esmonde and colleagues reported 29 patients with subacute spongiform encephalopathy (CJD) who had donated blood prior to onset and who excluded the possibility of transmission of the disease based on geographic data because the blood donors’ CJD within the area of their blood donation The incidence did not increase. However, the potential problem with this method is that it is not clear when viremia occurs during the course of disease or during the incubation period, which is very different from the findings of iatrogenic CJD in the application of human growth hormone therapy. Because blood transfusion is often a serious disease, there is a disturbance of the blood-brain barrier, and the authors speculate that CJD virus reaches the nervous system during the viremia of CJD. The possibility of delivery through blood transfusions can only be applied with the aid of every blood unit offered to CJD patients