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根据动脉血气对41例药物过量患者的酸碱状态及影响因素进行分析评估。95%的患者为安眠镇静药、镇痛药和抗精神病药过量,其中深昏迷或生命征不稳定者占70.7%。结果表明,酸碱失衡的发生率高,在重症组达90%。有56.1%的患者发生代谢性酸中毒,其中5例 pH≤7.25者均为合并呼吸性酸中毒的重症患者,表明通气障碍在药物过量者酸碱失衡中的重要作用。呼吸性碱中毒亦很常见,其发生率在轻、重组分别为66.7%和37.3%。分析通气改变的影响因素,并就这类患者治疗中静脉补碱和中枢兴奋剂应用问题进行探讨。
According to arterial blood gas in 41 patients with overdose of acid-base status and influencing factors were analyzed and evaluated. Ninety-five percent of patients are hypnotic sedatives, analgesics and antipsychotics, with 70.7% of whom have deep coma or vital signs. The results showed that the incidence of acid-base imbalance in the severe group reached 90%. Metabolic acidosis occurred in 56.1% of the patients, and 5 of them, pH≤7.25, were all severe patients with respiratory acidosis, indicating an important role of ventilation in the acid-base imbalance of overdosages. Respiratory alkalosis is also very common, the incidence of light, recombinant were 66.7% and 37.3%. Analyze the influencing factors of ventilatory changes, and discuss the application of mid-caecum and central stimulant in such patients.