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某些恶性肿瘤及非恶性肿瘤患者预后较差,联合应用环磷酰胺和强的松可改善结节性多动脉炎、淋巴瘤样肉芽肿、Wegener 肉芽肿和特发性肺纤维化等疾病的生存期,但也有严重或致命性毒性。作者在15个月内观察到13例用环磷酰胺加强的松治疗的病人中4例出现急性呼吸衰竭,9例无并发症。病例报告患呼吸衰竭的4例是:①例1:男性,56岁,患坏死性肉芽肿性炎症和 Wegener 肉芽肿,用环磷酰胺150mg/d 加强的松,经开胸活检证实药物性肺损害和卡氏肺孢子虫肺炎
Some malignant tumors and non-malignant tumors in patients with poor prognosis, combined with cyclophosphamide and prednisone can improve polyarteritis nodosa, lymphoma-like granuloma, Wegener granulomatosis and idiopathic pulmonary fibrosis and other diseases Survival, but also serious or fatal toxicity. In 15 months, the authors observed acute respiratory failure in 4 of 13 patients treated with cyclophosphamide plus prednisone, and 9 patients had no complications. Case Reports Four cases of respiratory failure were: ① Case 1: Male, 56 years old with necrotizing granulomatous inflammation and Wegener’s granulomatosis. Cyclophosphamide plus 150 mg / Damage and Pneumocystis carinii pneumonia