论文部分内容阅读
目的:探讨经术中留置药物输注装置(DDS)行动脉区域栓塞灌注治疗不能切除胰头癌的临床应用价值。方法:15例经手术探查无法切除并病理证实为胰头癌的患者术中留置DDS于肿瘤供血血管,术后经DDS行动脉区域栓塞灌注化疗药物。化疗后对患者的近期疗效、不良反应进行评价。结果:15例患者中近期疗效CR 0例,PR 10例,SD 5例,PD 0例,总有效率(CR+PR)66.7%。疼痛缓解率77.3%(11例)。不良反应中主要为胃肠道反应、骨髓抑制,无严重肝肾功能损害及死亡等严重并发症。15例患者DDS位置固定稳妥,未出现导管移位情况。结论:经术中留置DDS行动脉区域栓塞灌注化疗可明显提高无法切除的胰头癌患者的近期疗效,其操作安全可靠,且不良反应少。
Objective: To investigate the clinical value of intra-arterial embolization of indwelling drug infusion device (DDS) in the treatment of unresectable pancreatic head cancer. Methods: Fifteen patients who had unresectable resection and pathologically confirmed pancreatic ductal carcinoma were sacrificed with DDS in the blood supply to the tumor, and chemoembolized with chemotherapeutic drugs through the DDS arteries. After chemotherapy for the patient’s immediate effect, adverse reactions were evaluated. Results: Among the 15 patients, there were 0 cases of CR, 10 cases of PR, 5 cases of SD, 0 cases of PD and 66.7% of total effective rate (CR + PR). The pain relief rate was 77.3% (11 cases). Adverse reactions mainly gastrointestinal reactions, bone marrow suppression, no serious liver and kidney dysfunction and death and other serious complications. Fifteen patients had stable DDS and no catheter displacement. CONCLUSION: Embolization and chemoembolization of artery in DDS artery can significantly improve the short-term curative effect of patients with unresectable pancreatic head cancer, and its operation is safe and reliable with few adverse reactions.