目的　探讨孕妇血浆纤维结合蛋白 (fibronectin ,FN)的变化及对妊娠结局的影响。方法　 2 0 0 1年 12月至 2 0 0 2年 12月采用酶联免疫固相吸附法测定 110例妊娠 2 0～ 2 8周妇女FN值 ,并观察妊娠结局。结果　胎膜早破、早产组FN明显低于对照组 (P <0 0 1) ,宫内感染、产褥感染发生率明显高于对照组 (P <0 0 0 1)。结论　FN水平降低 ,可作为预测胎膜早破发生、早产及提示感染的早期监测指标 Objective To investigate the changes of plasma fibronectin (FN) in pregnant women and its effect on pregnancy outcome. Methods From December 2001 to December 2002, the FN of 110 cases of pregnant women with 20 ~ 28 weeks of pregnancy were determined by enzyme-linked immunosorbent assay (ELISA), and the pregnancy outcome was observed. Results Premature rupture of membranes, FN in premature labor group was significantly lower than that in control group (P <0.01). The incidence of intrauterine infection and puerperal infection was significantly higher than that of control group (P <0.01). Conclusions The FN level is reduced, which can be used as an early monitoring indicator to predict the occurrence of premature rupture of membranes, premature labor and prompt infection