新喹诺酮类药物的发现,意外地扩展了人类用来治疗由分枝杆菌所引起的感染性疾病的药物应用范围。虽然在这类抑制细菌DNA旋转酶的抗菌药物中,主要化合物氟哌酸对分枝杆菌的作用不强,但其N-环丙基类似物环丙氟哌酸和三环的氟嗪酸却应当引起人们的注意。这些药物能迅速渗透进入哺乳动物细胞。这一特性对治疗细胞内致病菌(如结核分枝杆菌)是非常重要的。本文就已发表的有关新 The discovery of new quinolones surprisingly expanded the range of drugs that humans use to treat infectious diseases caused by mycobacteria. Although the main compound norfloxacin has a poor effect on mycobacteria in such antibacterial drugs that inhibit bacterial DNA gyrase, its N-cyclopropyl analogs ciprofloxacin and tricyclic It should attract people’s attention. These drugs quickly penetrate into mammalian cells. This feature is very important for the treatment of intracellular pathogens such as M. tuberculosis. This article has been published about the new