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青蒿素类药物是治疗疟疾的主要药物,其衍生物有青蒿琥酯、蒿甲醚和二氢青蒿素等。近年来研究发现,青蒿素及其衍生物具有明显的抗肿瘤作用。研究表明:青蒿素及其衍生物可以抑制或杀伤肿瘤细胞;抑制肿瘤细胞增殖与诱导肿瘤细胞凋亡;抑制血管生成;选择性杀伤肿瘤细胞;逆转肿瘤细胞的多重耐药;具有放射增敏效应。因青蒿素及其衍生物安全低毒,有望成为新型的广泛、高效、低毒的抗癌药物。
Artemisinin drugs are the main drugs for the treatment of malaria. Its derivatives include artesunate, artemether and dihydroartemisinin. In recent years, studies have found that artemisinin and its derivatives have a significant anti-tumor effect. Studies have shown that: Artemisinin and its derivatives can inhibit or kill tumor cells; inhibit tumor cell proliferation and induce tumor cell apoptosis; inhibit angiogenesis; selectively kill tumor cells; reverse multiple drug resistance in tumor cells; with radiosensitization effect. Because artemisinin and its derivatives are safe and low-toxic, it is expected to become a new type of broad, highly effective, and low-toxicity anticancer drug.