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本文观察了绿茶提取物抗肿瘤作用及其作用机理,实验发现,一定浓度的绿茶提取物,对体外培养的人胃腺癌细胞克隆生长具有明显的细胞毒作用,杀伤作用与药物浓度和作用时间成正相关。10-50mg/kg腹腔给药的抑瘤率为28～45%,并能使荷瘤小鼠脾脏T淋巴细胞~3H-TdR参入值(cpm)由750±60,提高到3727±392,口服给药500～1000mg/kg抑瘤率为32～40%。流式细胞光度术细胞动力学测定结果发现,茶叶提取物能阻断L_(1210)细胞由G_I期向S期合成。阻断作用是发生在细胞分化的早期阶段。
This article observed the anti-tumor effect of green tea extract and its mechanism of action. It was found that a certain concentration of green tea extract has obvious cytotoxicity on the growth of human gastric adenocarcinoma cells cultured in vitro. The killing effect is positive with the drug concentration and the action time. Related. The inhibition rate of intraperitoneal administration of 10-50mg/kg was 28-45%, and the 3H-TdR incorporation (cpm) of splenic T lymphocytes in tumor-bearing mice increased from 750±60 to 3727±392. The dose of 500 to 1000 mg/kg was 32 to 40%. Flow cytometric cell kinetics results showed that tea extracts could block L_(1210) cells from G_I to S phase synthesis. Blocking occurs during the early stages of cell differentiation.