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实验以75只氨基甲酸乙酯麻醉的大鼠进行。刺激坐骨神经,观察大鼠在吸入不同浓度低氧混合气体时,背侧海马诱发电位(Hippocampal Evoked Potential,HEP)和皮层诱发电位(Cortical Evoked Potential,COEP)的变化。低氧时,HEP的P_1和N_1波振幅均下降;N_1波振幅下降百分率大于P_1波;氧分压越小,时间越长,HEP的振幅下降就越大。缺氧早期,HEP振幅下降大于后期。恢复正常通气时,HEP的P_1波先于N_1波恢复到对照水平。低氧时,HEP振幅下降率略低于COEP,但两者无显著差异(P>0.05);HEP和心率变化相比较,P_1波振幅下降百分率明显大于心率下降百分率(P<0.01),表明HEP对缺氧更敏感。提示HEP可作为观察急性缺氧早期反应的指标。
Experiments were performed with 75 urethane anesthetized rats. The sciatic nerve was stimulated to observe the change of hippocampal Evoked Potential (HEP) and Cortical Evoked Potential (COEP) in rats exposed to different concentrations of hypoxia. Under hypoxia, the amplitude of P_1 and N_1 wave of HEP decreased; the amplitude of N_1 wave decreased more than P_1 wave; the smaller the oxygen partial pressure, the longer the HEP amplitude. Early hypoxia, HEP amplitude decreased more than late. When returning to normal ventilation, the P_1 wave of HEP returned to the control level before N_1 wave. HEP amplitude decreased slightly under hypoxia than that of COEP, but there was no significant difference between them (P> 0.05). Compared with heart rate, HEP amplitude decreased significantly (P <0.01), indicating that HEP More sensitive to hypoxia. HEP can be used as an indicator of early response to acute hypoxia.