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据报道,在代谢正常的人中发现了胰岛素自身抗体(IA-ab),这些人后来患了糖尿病,在新确诊的糖尿病患者和许多后来发生糖尿病的患者血清中也发现与其他免疫球蛋白起反应的另一种循环抗体即抗免疫球蛋白抗体(aIg-ab)。为估价这些抗体与糖尿病相关的特异性,本文测定了多种免疫疾病中的IA-ab、aIg-ab、免疫复合物和器官特异性抗体。 病人和方法:111价血清标本取自器官特异性和非器官特异性自身免疫疾病患者(包括新确诊的Graves病、原发性甲状腺机能减退症、慢性自身免疫性甲状腺炎、阿狄森氏病、慢性自身免疫性肝炎、恶性贫血、系统性红斑狼疮、类风湿性关节炎)。
Insulin autoantibodies (IA-ab) have been reported in people with normal metabolism who subsequently developed diabetes and also found to be associated with other immunoglobulins in sera of newly diagnosed and many later diabetics Another circulating antibody that reacts is the anti-immunoglobulin antibody (aIg-ab). To assess the diabetes-related specificity of these antibodies, IA-ab, aIg-ab, immune complexes and organ-specific antibodies were assayed for a variety of immune diseases. PATIENTS AND METHODS: 111-valent serum samples were obtained from patients with organ-specific and non-organ-specific autoimmune diseases including newly diagnosed Graves’ disease, primary hypothyroidism, chronic autoimmune thyroiditis, Addison’s disease , Chronic Autoimmune Hepatitis, Pernicious Anemia, Systemic Lupus Erythematosus, Rheumatoid Arthritis).