重症难治性休克是休克病程的最后阶段,出现难以治疗的微循环衰竭、顽固性低血压、多器官功能衰竭,它是当前休克研究的中心议题之一。至今有许多发病学问题尚未解决,如休克时产生的一系列细胞因子,谁是最初的启动机制?为什么拮抗细胞因子在临床上没有明显的效果?抗休克治疗后为 Severe refractory shock is the final stage of shock course, there are refractory microcirculation failure, intractable hypotension, multiple organ failure, it is one of the central topics of current shock research. So far, many epidemiological problems have not yet been solved, such as a series of cytokines produced in shock, who is the initial promoter mechanism? Why antagonistic cytokines in clinical no significant effect? ​​After anti-shock treatment