表皮生长因子受体(EGFR)是一种跨膜糖蛋白,它包括一个胞外配体结合区和一个具有酪氨酸激酶活性及信号传导功能的胞内区,EGF和转化生长因子-α(TGF-α)是其最重要的配体。其配体的结合可激活受体及其信号传导途径,并由此激活或调节细胞生长进程。该受体存在于源自所有3个胚细胞 Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that includes an extracellular ligand-binding domain and an intracellular domain that has tyrosine kinase activity and signaling capabilities. EGF and transforming growth factor-alpha ( TGF-α) is its most important ligand. Binding of its ligand activates receptors and their signaling pathways and thereby activates or regulates cell growth processes. This receptor is present in all 3 blast cells