神经钙蛋白(Calcineurin)是一种参与T细胞激活的酶,其抑制剂如环孢素和他利莫司被广泛用作免疫抑制剂,预防器官移植后的排斥反应。然而,目前上市的这类药物通常会产生严重的不良反应,尤其如环孢素有严重的肾毒性,限制了其临床应用。加拿大Isotechnika生物技术公司开发出新型神 Calcineurin is an enzyme involved in T cell activation and its inhibitors such as cyclosporine and thalidomide are widely used as immunosuppressants to prevent rejection after organ transplantation. However, the currently marketed drugs usually cause serious adverse reactions, especially if cyclosporine has severe nephrotoxicity, which limits its clinical application. Isotechnika Canada biotechnology company developed a new god