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１３０只大鼠经６０Ｃｏγ射线１０，３０，５０，６０Ｇｙ单次照射右腹部肝区，于照后０．５，１，２，３，６，９，１２个月分批活杀，通过光镜、电镜及图像分析，定性、定量地观察了肥大细胞（ＭＣ）在放射性肝纤维化中的变化规律．结果表明：３０Ｇｙ组动物肝脏发生了典型的慢性纤维化病变，其病变呈进行性发展，其中ＭＣ于照后１～２个月即见增多，胞体变大，尤以３～９个月为显著，并见脱颗粒现象．且ＭＣ增多和变大的高峰期恰与肝内结缔组织增生明显期相平行，而照后１２个月，纤维组织胶原化时，ＭＣ则趋于减少．表明ＭＣ参与了放射性肝纤维化的形成过程。最后，本文作者对其可能促进或直接参与放射性肝纤维化的形成机理等作了探讨．
One hundred and thirteen rats were irradiated with 10, 30, 50, 60Gy of 60Coγ rays for a single time in the right abdomen area, and were sacrificed at 0.5, 1, 2, 3, 6, 9 and 12 months after irradiation. , Electron microscopy and image analysis. The changes of mast cells (MC) in radiation-induced liver fibrosis were observed qualitatively and quantitatively. The results showed that typical chronic fibrosis occurred in the liver of 30 Gy animals, and the lesions progressed progressively. The incidence of MC increased 1 to 2 months after irradiation and the cell body became larger, especially in 3 to 9 months , And see the phenomenon of degranulation. And MC increased and larger peak just coincide with the obvious intrahepatic connective tissue hyperplasia, and 12 months after irradiation, collagen fibers, MC tends to decrease. That MC is involved in the formation of radiation-induced liver fibrosis. Finally, the authors discuss the possible mechanism that they may promote or directly participate in the formation of radiation-induced liver fibrosis.