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目的探讨宫颈癌ⅡB~ⅣA期患者应用简化调强放疗手段与腔内治疗及同步化疗联合治疗的临床效果及相关毒副反应。方法 80例宫颈癌ⅡB~ⅣA期患者,随机分为对照组和观察组,各40例。对照组应用常规放疗治疗,观察组采用简化调强放疗联合腔内治疗及同步化疗治疗,比较两组疗效及毒副反应情况。结果观察组患者总有效率为92.5%,对照组为72.5%,差异具有统计学意义(P<0.05)。观察组患者1年生存率为97.5%(39/40),对照组为92.5%(37/40),比较差异无统计学意义(P>0.05)。观察组放射性直肠炎9例,放射性膀胱炎1例,毒副反应率为25.0%;对照组放射性直肠炎17例,放射性膀胱炎5例,毒副反应率为55.0%,比较差异具有统计学意义(P<0.05)。结论中晚期ⅡB~ⅣA期患者应用简化调强放疗方案与腔内治疗及同步化疗联合治疗,可显著提高临床效果,降低毒副反应发生风险,具有非常重要的应用价值。
Objective To investigate the clinical effects and related toxicities and side effects of simplified intensity-modulated radiotherapy and endovascular and synchronous chemotherapy in patients with stage ⅡB-ⅣA cervical cancer. Methods Eighty patients with cervical cancer ⅡB ~ ⅣA were randomly divided into control group and observation group, 40 cases in each. The control group was treated with conventional radiotherapy. The observation group was treated with simplified intensity modulated radiotherapy combined with intracavitary and synchronous chemotherapy. The curative effect and toxicity were compared between the two groups. Results The total effective rate was 92.5% in the observation group and 72.5% in the control group, the difference was statistically significant (P <0.05). The 1-year survival rate was 97.5% (39/40) in the observation group and 92.5% (37/40) in the control group, with no significant difference (P> 0.05). In the observation group, 9 cases of radiation proctitis and 1 case of radiation cystitis showed a rate of 25.0%; in the control group, 17 cases of radiation proctitis and 5 cases of radiation cystitis with a rate of 55.0%, the difference was statistically significant (P <0.05). Conclusions The application of simplified intensity-modulated radiation therapy combined with endovascular therapy and concurrent chemotherapy in patients with stage IIB-IVA advanced stage can significantly improve the clinical effect and reduce the risk of adverse reactions, which is of great value.