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目的探讨血管活性物质尾加压素Ⅱ(UⅡ)在冠心病患者体内的表达及其变化。方法采用放射免疫法测定50例冠心病患者及20例健康体检者的血浆UⅡ的水平。结果(1)健康对照组静脉血浆UⅡ含量为3.70±1.30 pg/ml,冠心病患者的血浆UⅡ含量为1.61±1.02 pg/ml,两者有统计学差异(P=0.000)。冠心病患者中稳定性心绞痛者血浆UⅡ含量为2.62±1.20 pg/ml,不稳定心绞痛者UⅡ含量为1.39±0.80 pg/ml,急性心肌梗死者UⅡ含量为1.04±0.45 pg/ml,3组之间有显著性差异(P=0.004)。(2)冠心病患者中冠脉血管有闭塞组静脉血浆UⅡ含量为1.29±1.02 pg/ml,单纯狭窄组UⅡ含量为1.76±1.00 pg/ml,两者无统计学差异(P=0.131)。(3)经皮腔内冠状动脉成型术(PTCA)及支架植入术后,出现再狭窄患者组血浆UⅡ含量为2.28±0.94 pg/ml,而其他病人的血浆UⅡ含量为1.40±0.96 pg/ml,两者有统计学差异(P=0.008)。(4) PTCA治疗前后,股动脉血浆UⅡ的含量分别为1.18±1.14、2.22±1.77 pg/ml,两者有统计学差异(P=0.001)。结论UⅡ可能参与了冠心病的发病;在PTCA治疗后出现支架内再狭窄中可能起作用。
Objective To investigate the expression and change of vasopressin Ⅱ (UⅡ) in patients with coronary heart disease. Methods Radioimmunoassay was used to detect plasma UⅡ levels in 50 patients with coronary heart disease and 20 healthy subjects. Results (1) The content of UⅡ in venous plasma was 3.70 ± 1.30 pg / ml in healthy controls and 1.61 ± 1.02 pg / ml in patients with coronary heart disease (P = 0.000). The UⅡcontent in patients with coronary heart disease was 2.62 ± 1.20 pg / ml for stable angina pectoris, 1.39 ± 0.80 pg / ml for unstable angina pectoris, and 1.04 ± 0.45 pg / ml for acute myocardial infarction There was a significant difference (P = 0.004). (2) The content of UⅡin venous plasma of patients with coronary artery occlusion in coronary heart disease was 1.29 ± 1.02 pg / ml, while that of simple stenosis group was 1.76 ± 1.00 pg / ml. There was no significant difference between the two groups (P = 0.131). (3) Percutaneous transluminal coronary angioplasty (PTCA) and stenting, the level of plasma UⅡ in patients with restenosis was 2.28 ± 0.94 pg / ml, while that of other patients was 1.40 ± 0.96 pg / ml, there was a significant difference between the two (P = 0.008). (4) The contents of UⅡ in femoral artery before and after PTCA were 1.18 ± 1.14 and 2.22 ± 1.77 pg / ml, respectively, with statistical significance (P = 0.001). Conclusion UⅡ may be involved in the pathogenesis of coronary heart disease. It may play a role in the in-stent restenosis after PTCA.