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目的探讨卵巢支持莱狄细胞瘤的临床特征、治疗和预后。方法 回顾性分析了我院1962—2002年治疗的11例卵巢支持莱狄细胞瘤患者的临床和病理资料。结果11例患者中,病理分化程度:高分化7例,中分化3例,低分化1例。临床分期:Ⅰ a期9例,Ⅱc期及Ⅲc期各1例。临床症状:腹部包块8例;去女性化及男性化表现共6例,其中3例行血清睾酮水平测定,均不同程度升高;月经增多、绝经后阴道出血等女性化表现者5例,其中1例同时具有女性化及男性化表现。合并症:5例合并与雌激素相关的疾病,包括子宫肌瘤、子宫内膜增生等,2例患者先后患乳腺癌。治疗:11例患者均行手术治疗,其中5例肿瘤分化不良或Ⅱ～Ⅲ期者,术后行系统性巩固化疗。随诊:随诊时间为6个月至34年,中位数随诊时间为7年,无一例死于本病。3例患者保留生育功能,均于术后1—3个月恢复月经,其中1例已生育。结论卵巢支持莱狄细胞瘤预后良好。早期、高分化者,可单纯手术治疗。分化不良或晚期肿瘤患者,术后应予巩固化疗。有生育要求者,可保留生育功能。
Objective To investigate the clinical features, treatment and prognosis of ovarian support Ledi cell tumor. Methods The clinical and pathological data of 11 patients with Ovarian Lymphocytoma who were treated in our hospital from 1962 to 2002 were retrospectively analyzed. Results Among the 11 patients, the pathological differentiation was highly differentiated in 7 cases, moderately differentiated in 3 cases and poorly differentiated in 1 case. Clinical stage: stage Ⅰ a in 9 cases, stage Ⅱc and stage Ⅲc in 1 case. Clinical symptoms: 8 cases of abdominal mass; to feminization and masculine manifestations of a total of 6 cases, of which 3 cases of serum testosterone levels were increased to varying degrees; increased menstruation, vaginal bleeding after menopause and other feminized performance in 5 cases, One case of both feminization and masculine performance. Comorbidity: 5 cases combined with estrogen-related diseases, including uterine fibroids, endometrial hyperplasia, 2 patients had breast cancer. Treatment: 11 patients underwent surgical treatment, including 5 cases of poorly differentiated tumors or stage Ⅱ ~ Ⅲ, postoperative systemic consolidation chemotherapy. Follow-up: The follow-up time was 6 months to 34 years. The median follow-up time was 7 years. None of the patients died of this disease. Three patients retained reproductive function, menstruation was resumed 1-3 months after surgery, of which 1 had been born. Conclusion The ovarian support for Lidell’s tumor has a good prognosis. Early, well-differentiated, can be a simple surgical treatment. Poorly differentiated or advanced cancer patients should be cured after chemotherapy. Have reproductive requirements, can retain reproductive function.