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目的:对结直肠癌患者术后监测血清结直肠癌抗原和癌胚抗原,旨在早期发现术后复发或转移。方法:用酶标抗结直肠癌抗原单克隆抗体和酶标抗癌胚抗原,检测97例结直肠癌术后患者血清结直肠癌抗原和癌胚抗原,每月1次,历时18～24个月。结果:结直肠癌抗原和癌胚抗原阳性率分别为64.7％和53.0％,假阴性率分别为35.2％和47％,两者合用其中一项阳性率为82.4％,假阴性率为17.6％,故两者同时检测具有互补作用。血清结直肠癌抗原和癌胚抗原异常早于临床复发或转移约2～3个月。结论:检测血清结直肠癌抗原和癌胚抗原可早期发现结直肠癌术后复发或转移。
OBJECTIVE: To monitor serum colorectal cancer antigens and carcinoembryonic antigen after colorectal cancer patients, aiming at early detection of postoperative recurrence or metastasis. METHODS: Enzyme-labeled monoclonal antibodies against colorectal cancer antigens and enzyme-labeled anti-carcinoembryonic antigen were used to detect serum colorectal cancer antigens and carcinoembryonic antigen in 97 patients with colorectal cancer after surgery, once a month, and lasted 18 to 24 months. month. Results: The positive rates of colorectal cancer antigen and carcinoembryonic antigen were 64.7% and 53.0%, respectively, and the false negative rates were 35.2% and 47%, respectively. One of the positive rates was 82.4% and the false negative rate was 17.6%. Therefore, the simultaneous detection of the two has a complementary effect. Serum colorectal cancer antigens and carcinoembryonic antigen abnormalities are approximately 2 to 3 months earlier than clinical recurrence or metastasis. Conclusion: Detection of serum colorectal cancer antigens and carcinoembryonic antigen can be early detection of colorectal cancer recurrence or metastasis.